积极监测前列腺癌患者的干预措施:叙事性审查
Simran Gill1, Runzhi Chen2, Benjamin W Lamb1,3,4
1Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
BJU international
|October 6, 2025
概括
在主动监测 (AS) 上,早期前列腺癌的非手术干预表明有前途. 雄激素受体通路抑制剂 (ARPIs) 可能会延迟进展,而生活方式的改变提供了耐受良好的选择,但需要更多的研究.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 基于证据的医学 基于证据的医学
背景情况:
- 积极监测 (AS) 是早期前列腺癌 (PCa) 的管理策略.
- 需要评估非手术干预措施来管理AS期间的PCa.
- 关于这些干预措施的当代证据需要综合.
研究的目的:
- 审查目前关于早期前列腺癌患者进行非手术干预的证据.
- 评估各种干预措施的有效性和安全性.
主要方法:
- 在PubMed,Medline和Embase数据库的文献搜索 (2011年至今).
- 包括随机对照试验 (RCT) 和队列研究.
- 专注于针对AS的PCa患者的干预.
主要成果:
- 雄激素受体通路抑制剂 (ARPI) 显示出延缓PCa进展的潜力,但有毒性问题.
- 营养药品,饮食和运动都能耐受,但缺乏大规模的RCT证据表明瘤效益.
- 生物标志物和标准化的AS标准是需要更好的风险分层和监测.
结论:
- 目前对AS干预的证据主要来自小型研究.
- 在高风险患者中考虑短期ARPI;在低风险患者中考虑生活方式干预.
- 包含生物标志物的大型RCT对于验证干预和长期结果至关重要.
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