在眼科瘤学中基于血液的无细胞DNA
Jasmine H Francis1,2, David H Abramson1,2
1Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Translational vision science & technology
|October 6, 2025
概括
基于血液的无细胞DNA (cfDNA) 显示出在眼科瘤学中作为液体活检的前景. 本综述探讨了其在各种眼睛癌症的应用,包括眼膜黑色素瘤和视网膜母细胞瘤,用于诊断和治疗监测.
科学领域:
- 眼科瘤学 眼科瘤学
- 液体活检检查 液体活检检查
- 生物标志物发现发现
背景情况:
- 无细胞DNA (cfDNA) 是瘤学中重要的液体活检生物标志物.
- 它在眼科瘤学的潜力是一个新兴的研究领域.
- 本综述侧重于基于血液的cfDNA在眼癌中的应用.
研究的目的:
- 审查目前血液基cfDNA在眼科瘤学的应用.
- 要突出应用在皮膜黑色素瘤,视网母细胞瘤,结膜瘤,胆管转移,不确定的胆管病变和眼球囊细胞瘤.
- 评估cfDNA在眼癌中的诊断和预后潜力.
主要方法:
- 在主要数据库 (MEDLINE,PubMed,科学网,Scopus) 进行系统的文献搜索.
- 搜索时间框架:2017年10月至2025年6月.
- 数据提取的重点是瘤类型,队列大小,cfDNA测定细节,分析的基因,性能指标和临床影响.
主要成果:
- 卵巢黑色素瘤是血液基cfDNA最受研究的领域,目前正在对原发性和转移性疾病进行评估.
- 使用cfDNA的视网母细胞瘤研究是有限的,但正在增长.
- 对于结膜瘤,冠状腺转移,不确定的病变和眼球囊细胞瘤,存在极少但有前途的研究.
结论:
- 无细胞DNA (cfDNA) 弥合了眼科瘤学的基础研究和临床实践.
- 潜在的应用包括诊断,预后,残留疾病监测,治疗选择和监测治疗反应.
- cfDNA可以作为检测新克隆和复发性疾病的生物标志物.
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