根据个人特征和查史,在结直肠癌查计划中检测晚期腺瘤的风险
Mercedes Vanaclocha-Espí1, Paula Romeo-Cervera1, Susana Castan-Cameo2
1Foundation for the Promotion of Health and Biomedical Research-Public Health Research FISABIO-Public Health Research, Valencia, Spain.
International journal of cancer
|October 6, 2025
概括
查史和人口统计学影响结肠直肠癌查中的晚期腺瘤检测. 诸如先前的阴性测试和便隐性血液水平等因素可以预测风险,从而实现量身定制的查策略.
科学领域:
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 晚期腺瘤 (AA) 是结直肠癌查计划 (CRCSP) 的关键指标.
- 了解影响AA检测的因素对于优化查有效性至关重要.
- 个人查史和人口特征可能会影响检测AA的可能性.
研究的目的:
- 调查个人查史和人口因素对检测晚期腺瘤 (AA) 风险的影响.
- 分析这些风险在大量人口队列中的初始和随后的查出席.
主要方法:
- 在瓦伦西亚地区CRCSP (2010-2018) 中对50-69岁的人进行了回顾性研究.
- 分析变量包括性别,年龄,以前的负面便隐性血液测试 (FOBT) 和便血红蛋白度 (Prev-f-Hb).
- 用于计算AA检测的几率比率 (OR) 的物流多变量模型.
主要成果:
- 在男性和60-69岁的年龄组中观察到更高的AA风险.
- 在随后的临床上,增加的Prev-f-Hb水平显著增加了AA风险,与剂量-反应关系有关.
- 相反,以前有四到五次负面FOBT的个体显示AA检测的风险降低.
结论:
- 人口特征,如性别和年龄,与AA检测风险有关.
- 查史,特别是以前的负面FOBT结果和便Hb水平,提供了有价值的预测信息.
- 这些发现支持开发适应风险的结直肠癌查策略.
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