复发性转移性多发性硬化症与异菌口腔微生物组有关
Sukirth M Ganesan1, Meeta Yadav2, Sudeep Ghimire2
1Department of Periodontics, University of Iowa College of Dentistry and Dental Clinics, Iowa City, Iowa, USA.
Annals of clinical and translational neurology
|October 6, 2025
概括
患有多发性硬化症 (MS) 的患者口腔微生物组不同,表现出改变的细菌组成和免疫反应. 这种口腔失生症可能作为MS相关免疫变化的生物标志物.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 多发性硬化症 (MS) 是一种慢性自身免疫性疾病,影响中枢神经系统.
- 肠道微生物组在多发性硬化症中的作用是已知的,但口腔微生物组的关联是不太了解的,特别是在北美人口中.
研究的目的:
- 研究与健康对照组 (HC) 相比,复发性复发性多发性硬化症 (RRMS) 患者的口腔细菌组成,功能途径和免疫特征.
- 在RRMS中探索口腔微生物群和唾液细胞因子之间的关系.
主要方法:
- 来自60名RRMS患者和44名HC患者的唾液样本使用16SrRNA测序分析了细菌组成.
- 使用PICRUSt2推断了功能途径,并通过多重免疫试验量化了唾液细胞因子.
- LEfSe和随机森林模型确定了关键类型,斯皮尔曼分析评估了微生物群-细胞因子相关性.
主要成果:
- RRMS患者表现出明显的口腔微生物群落,与增加的细菌菌群与固菌菌群的比率.
- 在RRMS中丰富的种群包括Campylobacter,Lachnoanaerobaculum和Porphyromonas;脂多糖生物合成途径也被提升.
- 在RRMS患者中,增高的促炎细胞因子 (IFN-γ,IL-6) 与改变的微生物组相关.
结论:
- 这项研究揭示了北美RRMS患者的口腔微生物群与宿主相互作用,突出了微生物失调,功能途径改变和免疫失调.
- 口腔微生物组具有作为MS相关免疫变化的生物标志物的潜力.
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