一个错误的低乳酸:由于β-基酸盐干扰而导致血液气体和核心实验室仪器之间的乳酸测量差异 - 一个案例报告
Nadia M Alqurini1, Bhawana Adhikari2, Hoda A Hagrass2
1Department of Nephrology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Laboratory medicine
|October 6, 2025
概括
增加的体可以干扰实验室的乳酸盐测试,导致不准确的结果. 这种干扰在急性骨髓性白血病和糖尿病酸性脂肪酸症中可见,可能会延迟关键诊断.
科学领域:
- 临床化学 临床化学
- 医学诊断 医学诊断 医学诊断
- 血液学 血液学 血液学
背景情况:
- 准确的实验室检测对于患者的诊断和管理至关重要.
- 解释结果,包括潜在的假阳性/假阴性,对于临床决策至关重要.
研究的目的:
- 报告一个显著的乳酸测量差异的情况.
- 为了确定干扰乳酸测试的原因.
主要方法:
- 一个患有急性髓性白血病和糖尿病酸性脂肪酸症的患者的案例研究.
- 乳酸水平差异的分析.
- 稀释和尖峰实验以调查干扰.
主要成果:
- 在乳酸测量中观察到临床上显著的差异.
- 升高的β-基酸盐 (体) 干扰了乳酸盐测定.
- 在使用特林德反应的仪器中发现了潜在的干扰.
结论:
- 体干扰可能导致不准确的乳酸读数.
- 这种干扰可能会延迟对患者危急病情的认知.
- 实验室协议可能需要审查以解决此类干扰.
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