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Updated: Jan 15, 2026

A Reporter Based Cellular Assay for Monitoring Splicing Efficiency
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对2'-O-甲基RNA反意义寡核酸具有有限的酸链接的系统评估,以实现高效的拼接切换

Suxiang Chen1,2, Bal Hari Poudel1,2,3, Rakesh N Veedu1,2,3

  • 1Personalised Medicine Centre, Health Futures Institute, Murdoch University, Murdoch, Western Australia 6150, Australia. R.Veedu@murdoch.edu.au.

Chemical communications (Cambridge, England)
|October 6, 2025
PubMed
概括

设计具有特定3'-end链接的2'-O-甲基 (2'-OMe) 反意义寡核酸 (ASO) 增强了外因子跳转效率和RNA结合. 这种方法优化了采用较少酸 (PS) 链接的拼接切换ASO.

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