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上腺素通过受体诱导塞尔托利细胞铁死 脱敏 引起与压力相关的男性生殖功能障碍

Lingyu Zhang1, Shanfeng Gao1, Xiaofan Xiong2

  • 1Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|October 6, 2025
PubMed
概括

心理压力通过诱导塞尔托利细胞通过北上腺素 (NE) 诱导ferroptosis损害男性生育能力. 使用普拉诺洛尔阻断β-上腺素受体 (β-ARs) 可以防止这种损伤,改善精子生产.

关键词:
铁性化 (ferroptosis) 是一种造成男性生殖器损伤.北上腺氨酸 (norepinephrine) 是一种心理压力 心理压力塞尔托利细胞的细胞.

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