牙周炎与囊状内动脉瘤破裂之间的关联:一个多中心横截面研究
Wentao Gong1,2, Jia Sun3,4, Tonghui Liu5
1Department of Neurointervention, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Neurosurgical review
|October 6, 2025
概括
牙周炎显著增加了状内动脉瘤 (SIA) 破裂的风险,特别是在较小的动脉瘤中. 牙疾病的严重程度与破裂风险的增加相关,突出显示了口腔健康和脑动脉瘤结果之间的潜在联系.
科学领域:
- 神经学 神经学
- 牙周病学 牙周病学
- 血管医学 血管医学
背景情况:
- 囊内动脉瘤 (SIA) 构成严重的健康风险,破裂导致脑下关节下出血.
- 系统性疾病,包括口腔健康在SIA破裂中的作用仍然是积极调查的领域.
- 牙周炎是一种慢性炎症性牙疾病,已被探索其潜在的全身炎症影响.
研究的目的:
- 调查牙周炎与内动脉瘤 (SIA) 的破裂之间的关联.
- 分析牙周病严重程度和SIA破裂风险之间的剂量反应关系.
- 根据动脉瘤特征,检查协会中的子组变异.
主要方法:
- 一项涉及622名患者的队列研究,涉及3家医院的716名SIA (破裂和未破裂).
- 进行牙周检查以诊断牙周炎,并使用临床附着损失 (CAL) 和探针深度 (PD) 评估严重程度.
- 采用多变量通用线性混合效应模型来分析牙周炎/牙炎和动脉瘤破裂之间的关联,包括子组和趋势分析.
主要成果:
- 牙周炎与SIA破裂有显著的相关性 (OR = 2.65,p < 0.001).
- 与较大的动脉瘤 (OR = 1.76, p = 0.039) 相比,动脉瘤直径≤5毫米 (OR = 4.04,p < 0.001) 的相关性更强.
- 观察到显著的剂量反应关系:增加CAL和PD (≥5毫米) 与更高的破裂风险相关.
结论:
- 牙周炎显著与状内动脉瘤破裂有关.
- 这种联系在较小的动脉瘤中最明显,并且随着牙周病的严重程度的增加而加强.
- 需要进一步的前性研究来确认因果关系.
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