相关实验视频
Updated: Jan 15, 2026

12:46
Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
Published on: August 17, 2022
3.0K
免疫检查点抑制剂相关心肌炎患者的细胞因子分析:一个试点研究
Siqi Li1, Kazuko Tajiri2,3, Yuki Ishizuka1,4,5
1Department of Cardiology, Institute of Medicine, University of Tsukuba, Tsukuba, 305-8575, Ibaraki, Japan.
Molecular biology reports
|October 6, 2025
概括
在免疫检查点抑制剂 (ICI) 治疗过程中,细胞因子概况发生变化. 特定的基线和治疗后的细胞因子水平可以预测ICI相关心肌炎,有助于患者管理.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
背景情况:
- 免疫检查点抑制剂 (ICI) 是有效的癌症治疗方法,但可能导致严重的心血管事件.
- 与ICI相关的心肌炎是一种罕见但危及生命的并发症.
- 生物标志物对于ICI诱导的心肌炎的早期检测和管理是必要的.
研究的目的:
- 调查与ICI诱导心肌炎相关的细胞因子概况.
- 评估这些细胞因子配置文件的预测价值.
主要方法:
- 试点研究涉及16名接受ICI治疗的患者 (6名心肌炎患者,10名对照患者).
- 在基线和第一 ICI 周期后收集的血清样本.
- 使用半定量膜基阵列分析了80种人类细胞因子.
主要成果:
- 在ICI后,两组都显示IL-1β/IL-2增加,CCL4,CXCL5,血管原蛋白,EGF,IL-10减少.
- 心肌炎组的基线G-CSF,IL-6,CXCL13升高,IL-10降低.
- 在ICI后,心肌炎组显示出更高的CXCL13,IL-6,瘦素水平.
结论:
- 与ICI相关的心肌炎发生明显的细胞因子概况变化.
- 以前存在的免疫失调或增加的ICI反应可能会导致心肌炎.
- 需要进一步的研究来验证这些预测生物标志物.
更多相关视频
相关概念视频
Myocarditis II: Clinical Features and Diagnostic Tests
265
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
265
Myocarditis I: Introduction
369
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
369
Myocarditis III: Medical Management
174
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
174
Myocarditis IV: Nursing Management
205
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
205
Acute Coronary Syndrome III: Diagnostic Studies
213
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
213
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
794
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
794

