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减肥手术后与药物相关的再入院的患病率:一项追溯观察性研究
Jurjen S Kingma1,2, Cindy Loh1,3, Ingo A Eland4
1Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, Utrecht, The Netherlands.
International journal of clinical pharmacy
|October 6, 2025
概括
减肥手术后与药物相关的再入院是常见的,影响13.7%的非计划性再入院. 许多这些事件,特别是那些涉及处方错误的事件,可以通过更好的药物管理和患者教育来预防.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 腹部外科手术可以改变口服药物的疗效,需要量身定制的药物治疗.
- 手术后未能调整药物可能导致药物不良事件和重入医院.
- 减肥手术后与药物相关的再入院的患病率尚未得到充分确立.
研究的目的:
- 为了确定与药物相关的再入院的患病率,在腹部外科手术后两年内.
- 确定可能可预防的与药物相关的再入院,并分析相关因素.
- 记录重新入院的原因,涉及的药物和药物错误.
主要方法:
- 在一次性减肥手术后两年内对非计划性再入院的回顾性观察性研究.
- 对患者病历进行查,以确定与药物相关的潜在再入院.
- 使用Kramer,Schumock & Thornton修改的算法对因果关系和可预防性的独立评估.
主要成果:
- 606例非计划性再入院病例中有13.7%与药物相关,发生在手术后152天的中位数.
- 43.3%的与药物相关的再入院被认为是可能可以预防的.
- 常见的原因包括腹痛和感染;经常相关的药物是PPI,阿片类药物和抗生素. 处方错误和不遵守是关键的药物错误.
结论:
- 与药物相关的再入院是减肥手术后经常出现的并发症.
- 优化药物治疗和提高患者教育对于这个患者群体至关重要.
- 对药物管理策略的进一步研究在腹部外科手术后是有必要的.
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