皮下酸甘用于预防儿科患者的放射性动脉封闭:一项随机临床试验
Jung-Bin Park1, Sang-Hwan Ji1, Eun-Hee Kim1
1Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
JAMA pediatrics
|October 6, 2025
概括
皮下注射的酸甘显著降低了放射性动脉封闭 (RAO) 在接受导管治疗的儿科患者. 这种干预通过预防血管和改善手术后的血液流动,促进更安全的恢复.
科学领域:
- 心血管医学 心血管医学
- 儿科干预心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 儿科患者面临更高的辐射动脉封闭 (RAO) 的风险,由于小血管和血管在导管后.
- 皮下酸甘氨酸有助于通过血管扩张成功进行放射性动脉导管注射,但其在去除后RAO预防中的作用尚不清楚.
研究的目的:
- 评估皮下酸甘在预防儿科患者RAO的疗效和安全性.
- 为了评估酸甘对放射性动脉血流和透术后 perfusion 的影响.
主要方法:
- 这是一项双盲随机临床试验,涉及3岁以下的儿科患者进行放射性动脉导管治疗.
- 患者在导管和去除之前接受皮下酸甘油或盐水,RAO通过反向巴博测试进行评估.
主要成果:
- 酸甘油显著降低了RAO发生率 (25.4%vs73.8%,P<.001),并改善了辐射动脉的峰值血流速度和输液指数.
- 两组之间没有观察到RAO持续时间,低血压或局部不良影响的显著差异.
结论:
- 皮下酸甘是有效的降低RAO发病率在儿科患者在导管后.
- 这种干预可以提高接受放射性动脉手术的幼儿的安全性和康复性.
相关概念视频
01:18Drug Delivery: Enteral Route
1.5K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.5K
01:16Antianginal Drugs: Nitrates and β-Blockers
1.3K
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
1.3K
01:23Antihypertensive Drugs: Vasodilators
2.0K
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
2.0K
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
231
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
231
01:20Angina V: Nursing Management
271
Angina, a symptom of myocardial ischemia, requires a structured nursing management approach to ensure effective care and prevent complications like myocardial infarction. Comprehensive nursing care involves assessing, diagnosing, planning, implementing interventions, and evaluating outcomes, all tailored to the individual patient's needs.Patient AssessmentNursing assessment begins with a detailed subjective evaluation of symptoms, which typically include chest pain or pressure radiating to the...
271
01:11Assessment of radial pulse
1.3K
Assessment of Radial Pulse
The radial pulse, located at the wrist, is often the preferred site for assessing peripheral pulse because of its accessibility and dependability. The process of determining the radial pulse involves several steps:
The radial pulse, located at the wrist, is often the preferred site for assessing peripheral pulse because of its accessibility and dependability. The process of determining the radial pulse involves several steps:
1.3K