相关实验视频
Updated: Jan 6, 2026

04:49
Technique for Intranasal Administration of α-Synuclein Aggregates
Published on: November 8, 2024
952
视觉幻觉在血清性迷幻药和莱维体疾病中的视觉幻觉
Nathan H Heller1,2, Frederick S Barrett1,2,3,4, Tobias Buchborn5
1Center for Psychedelic and Consciousness Research, Johns Hopkins University School of Medicine, Baltimore, MD 21224, United States.
Schizophrenia bulletin
|October 6, 2025
概括
莱维体疾病 (LBD) 中的视觉幻觉和迷幻药的使用共享神经通路. 通过比较这些情况,可以发现共同的皮质和血清素受体机制,有助于干预开发.
科学领域:
- 神经学 神经学
- 认知神经科学 认知神经科学
- 系统神经科学 系统神经科学
背景情况:
- 视觉幻觉 (VH) 是莱维体疾病 (LBD) 和使用血清类迷幻药 (SP) 的核心症状.
- 尽管有不同的原因,重叠的现象学和神经机制表明LBD和SP诱导的VH之间有共同的途径.
研究的目的:
- 为了比较现象学,皮质功能和LBD和SPs中的VH的血清调节.
- 探索在这些不同的条件下潜在的共享神经机制是VH的基础.
主要方法:
- 一个叙事综述综合了神经学,认知神经科学和系统神经科学的发现.
- 分析涉及人类受试者和动物模型的研究,检查皮质活动,神经调节机制和VH现象学.
主要成果:
- 无论是LBD还是SP,都有各种各样的视觉偏差,一些LBD特征反映了SP诱导的现象.
- 神经成像显示过度活跃的关联皮质和低活跃的感觉皮质的常见模式.
- 共同的神经调节发现包括血清素2A受体的参与和皮质刺激/抑制平衡的改变.
结论:
- 了解VH中共享的皮层和神经调节相似之处,可以阐明感官处理和幻觉产生之间的关系.
- 未来的研究使用实时神经成像在幻觉发作期间是确定共享的机制和开发有针对性的LBD干预的关键.
更多相关视频
相关概念视频
Hallucinogens and Psychedelics
555
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
555
CNS Stimulants: Psychedelic Agents
618
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
618
Positive Symptoms Schizophrenia: Hallucinations and Delusions
412
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Hallucinations
Hallucinations in...
412
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
490
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
490
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
1.8K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.8K
Parkinson's Disease: Treatment
931
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
931

