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Updated: Jan 15, 2026

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology
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肝蛋白激酶Cβ对抗p38MAPK以激活ERK1/2以在石化压力时失调胆汁脂质组成

Yaoling Shu1, Amit Rai1, Gina M Sizemore2

  • 1Department of Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.

American journal of physiology. Gastrointestinal and liver physiology
|October 6, 2025
PubMed
概括

这项研究揭示了肝脏蛋白激酶Cbeta (PKCβ) 如何调节肝脏基因表达和信号通路,影响胆汁酸代谢和胆固醇平衡在石化饮食下. 了解这个PKCβ/p38MAPK/ERK1/2轴为胆结石疾病提供了新的治疗点.

关键词:
胆汁酸的恒常性 胆汁酸的恒常性石质性饮食是一种石质性饮食.信号传导的信号传导.

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