在一般人群中评估代谢健康:对2015-2016年特罗姆索研究中的三个定义进行比较分析
Monika Lund Machlik1, Sameline Grimsgaard1, Laila A Hopstock2
1Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
PloS one
|October 6, 2025
概括
代谢健康肥胖症 (MHO) 的定义有很大差异,影响了流行率估计. 有效的公共卫生策略和临床治疗需要达成共识的定义.
科学领域:
- 肥胖问题研究研究
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 代谢健康肥胖 (MHO) 的概念具有显著的兴趣.
- 缺乏对代谢健康的标准化定义,阻碍了MHO研究.
研究的目的:
- 为了比较三种不同的代谢健康定义.
- 评估这些定义中代谢健康个体的流行率和重叠情况.
- 在代谢不健康的个体中分析代谢成分的频率.
主要方法:
- 利用了来自特罗姆索研究 (特罗姆索7) 的20581名成年人 (40-99岁) 的数据.
- 使用三个标准将参与者分类为代谢健康 (MH):A) ≤1/4代谢综合征 (MetS) 组件,B) 0/4 MetS组件,C) 0/3组件 (糖尿病,血压升高,腰比).
- 分析了按性别和BMI类别分层的流行率,重叠率和组件频率.
主要成果:
- 根据定义,新陈代谢健康 (MH) 患病率各不相同:定义A产生50% (女性) 和38% (男性) 的肥胖;定义B产生18% (女性) 和10% (男性);定义C产生29% (女性) 和18% (男性).
- 在女性和BMI较低的个体中,MH的患病率更高.
- 血压升高是代谢不健康个体中最常见的代谢异常.
结论:
- 在不同的定义中存在着MH患病率的显著差异.
- 对代谢健康的共识定义至关重要.
- 需要标准化定义,以告知公众预防和临床治疗策略.
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