患有风湿性肌肉骨疾病的患者的气象敏感性
Ulrich A Walker1, Katja Nettermann2, Sebastian Walker3
1Department of Rheumatology, University Hospital Basel, Basel, Switzerland.
PloS one
|October 6, 2025
概括
天气不会显著影响类风湿性关节炎 (RA),牛皮性关节炎 (PsA) 或性脊柱炎 (AS) 患者的类风湿性疾病活动,这些患者接受DMARD治疗. 研究发现,天气变量与自我评估的疾病活动得分之间没有临床显著的相关性.
科学领域:
- 类风湿病学 类风湿病学
- 环境医学 环境医学
- 临床研究 临床研究
背景情况:
- 类风湿性疾病,如类风湿性关节炎 (RA),牛皮性关节炎 (PsA) 和性脊柱炎 (AS) 可以显著影响患者的生活质量.
- 患者经常报告与天气相关的疾病活动的主观变化,这种现象被称为流星敏感性.
- 了解潜在的环境触发因素对于全面的患者管理至关重要.
研究的目的:
- 调查当地的天气条件与自我评估的类风湿病活动之间的关联.
- 为了确定RA,PsA或AS患者是否经历了与气象因素相关的疾病活动变化.
- 评估任何观察到的与天气有关的影响对疾病活动的临床意义.
主要方法:
- 一项前性多中心研究,涉及瑞士诊断患有RA,PsA或AS的成年患者.
- 患者使用网络应用程序报告他们的地理位置和疾病活动,使用例行评估患者指数数据3 (RAPID3) 评分.
- 通过回归分析,将RAPID3得分与前一周的天气数据和天气变化相关联.
主要成果:
- 分析了238名RA,PsA和AS患者 (61.3%为女性) 的队列.
- 在整体队列中,在RAPID3得分和气压之间观察到微弱的负相关性 (r = -0.167).
- 在AS和PsA患者的气象敏感小组中,观察到与气压的微弱负相关性,但效应大小不超过临床重要差异的最小值.
结论:
- 在接受DMARD治疗的RA,PsA和AS患者中,天气并未被确定为疾病活性的主要决定因素.
- 观察到的天气和疾病活动之间的相关性通常很弱,并且没有临床意义.
- 可能需要进一步的研究来探索其他可能影响这些患者群体疾病活性的潜在因素.
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