相关实验视频

Updated: Jan 15, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

微生物组研究中的多主题时间序列分析:系统性审查

Moiz Khan Sherwani¹, Matti O Ruuskanen², Dylan Feldner-Busztin³

¹Center for Evolutionary Hologenomics, GLOBE Institute, University of Copenhagen, Øster Farimagsgade 5, 1353 Copenhagen K, Denmark.

Briefings in bioinformatics

|October 6, 2025

概括

本综述系统地评估了纵向多omics集成的计算方法. 它确定了趋势和高性能框架,为推进生物学的综合数据科学提供了路线图.

科学领域:

综合生物学和数据科学
计算生物学是一种计算生物学.
系统生物学系统生物学

背景情况:

数据生成方面的进步为生物系统提供了新的见解.
整合跨尺度的时间变化是理解生物机制和表型的关键.
纵向的多学科研究正在增加,但分析方法仍在发展.

研究的目的:

系统地审查和评估用于纵向多omics集成的计算方法.
将现有方法分类和比较,重点关注四种研究类型:宿主/微生物组,仅宿主,仅微生物组和方法框架.
为这个领域的未来研究和应用提供路线图.

主要方法:

对纵向多omics集成的计算方法的系统文献综述.
研究的分类为宿主/微生物组,仅宿主,仅微生物组和方法框架.
基于性能,可解释性和易用性的方法的评估.

主要成果:

确定了纵向多omics集成的当前方法趋势.
突出广泛使用和高性能计算框架.
组织方法分为主题组:统计建模,机器学习,缩小维度和潜在因子方法.

结论:

在纵向多omics数据分析中需要标准化和评估的方法.
本综述为推进整合纵向数据科学提供了全面的概述和关键基础.
这些发现支持在这个快速发展的领域中进行可复制和可扩展的分析.

关键词:

与宿主相关的微生物群.机器学习是机器学习.多种主题的多种主题.统计建模统计建模时间序列时间序列.

更多相关视频

Guided Protocol for Fecal Microbial Characterization by 16S rRNA-Amplicon Sequencing

Guided Protocol for Fecal Microbial Characterization by 16S rRNA-Amplicon Sequencing

Published on: March 19, 2018

Tick Microbiome Characterization by Next-Generation 16S rRNA Amplicon Sequencing

Tick Microbiome Characterization by Next-Generation 16S rRNA Amplicon Sequencing

Published on: August 25, 2018

相关概念视频

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

Modern Molecular Taxonomy

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...