生物检测阴性巨细胞关节炎病例中的西格里斯特条纹:一个病例报告

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生物检测阴性巨细胞关节炎病例中的西格里斯特条纹:一个病例报告

Thomas W Cameron¹, Talhah Zubair², Siya Huo³

¹University of Minnesota Medical School, Twin Cities.

Ophthalmic surgery, lasers & imaging retina

|October 6, 2025

概括

巨细胞动脉炎 (GCA) 即使初始活检呈阴性,也会导致视力丧失. 眼睛的发现和重新评估对于及时的类固醇治疗至关重要,以防止永久的视力丧失.

科学领域:

眼科医生眼科眼科
类风湿病学类风湿病学
病理学病理学病理学

背景情况:

巨细胞动脉炎 (GCA) 是一种血管炎,可以导致不可逆转的视力丧失.
多发性肌痛风湿症 (PMR) 经常与GCA相关联.
动脉活检 (TAB) 是GCA的常见诊断工具.

研究的目的:

要突出一个双边视力损失的案例,由于GCA与最初负的TAB.
强调疑似GCA的眼科诊断的重要性.
为了强调在临床怀疑较高时对活检样本进行重新评估的必要性.

主要方法:

一个78岁的男性患有PMR和双边视力丧失的病例报告.
底部检查显示西格里斯特条纹和阿马尔三角形标志 (ATS).
光学连贯断层扫描 (OCT) 显示了偏中心急性中间巨病 (PAMM).
最初的负面TAB,然后再评估和确认GCA.
用静脉注射甲基prednisolone进行治疗.

主要成果:

患者在迅速接受类固醇治疗后经历了视觉改善.
最初的TAB是负的,但重新检查证实了GCA.
眼睛的发现对于指导诊断和治疗至关重要.

结论:

眼部诊断对于诊断GCA至关重要,特别是在负面活检时.
重新评估TAB标本可以在临床怀疑很高时确认GCA.
早期的类固醇治疗对于预防视力丧失和GCA系统性并发症至关重要.

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