从营养到智能疗法 皮肤病学应用的食物衍生的多糖:一篇综述
Minghui Sun1, Yibo Zhang2, Mingwei Zhou1
1Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
International journal of biological macromolecules
|October 6, 2025
概括
食物中的多糖提供了先进的皮肤疗法,克服了传统治疗的局限性. 它们的适应性结构可以通过新的系统进行有针对性的传递,以改善免疫调节,氧化还原平衡和伤口愈合.
科学领域:
- 皮肤病学 皮肤病学
- 生物材料科学 生物材料科学
- 食品科学 食品科学 食品科学
背景情况:
- 食品衍生的多糖在皮肤学中被认为具有生物功能性质.
- 局部治疗常常受到针对性差,不灵活性和安全问题的困扰.
研究的目的:
- 系统地审查用于皮肤应用的食品衍生的多糖.
- 探索它们的结构特征,功能机制和刺激反应策略.
- 评估它们在先进皮肤治疗中的潜力.
主要方法:
- 系统的文献审查,重点关注结构性质,功能机制和传递系统.
- 对刺激反应策略 (pH,ROS,酶) 的分析.
- 检查在水凝,微针,纳米颗粒和敷料中的应用.
主要成果:
- 食品中的多糖体表现出适应性结构和功能组,适用于皮肤应用.
- 刺激响应系统提高了精确的时空传递.
- 多糖在免疫调节,氧化还原平衡,微生物群调节和伤口愈合中发挥作用.
结论:
- 来自食物的多糖体显示出作为精密皮肤治疗的多功能治疗平台的前景.
- 挑战包括结构异质性和临床翻译障碍.
- 未来的方向包括数据库开发,高通量选和器官类型模型验证.
更多相关视频
12:02Automated Modular High Throughput Exopolysaccharide Screening Platform Coupled with Highly Sensitive Carbohydrate Fingerprint Analysis
Published on: April 11, 2016
11.9K
04:09Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
Published on: December 13, 2024
1.2K
相关概念视频
Glycosaminoglycans
6.9K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
6.9K
Clinical Applications of Epidermal Stem Cells
3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K
Biosynthesis of Polysaccharides
552
Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
552
Cellulose and Pectic Polysaccharides
4.6K
Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth. Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the...
As a cell matures, its cell wall specializes according to its type. For example, the...
4.6K
Reticular Dermis
4.4K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
4.4K
