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微生理系统作为人类暴露体项目的支柱

Fenna C M Sillé1, Lena Smirnova1, Thomas Hartung2

  • 1Center for Alternatives to Animal Testing (CAAT), Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health and Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

The Journal of biological chemistry
|October 6, 2025
PubMed
概括

微生理系统 (MPS) 通过对终身环境暴露进行建模来推进人类暴露的研究. 这些与人类相关的平台与人工智能集成,用于预测疾病,提供个性化的公共卫生策略.

关键词:
人类暴露ome暴露微生理系统的微生理系统新方法方法论新方法方法论器官在芯片上的器官风险评估 风险评估 风险评估毒理学 毒理学 毒理学

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Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
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