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Updated: Jan 15, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
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埃索梅普拉通过抑制小鼠中的有机阴离子转运体2来预防oxaliplatin诱导的外围神经病变

Manami Ueno1, Akihide Kobayashi2, Kenji Ikemura2

  • 1Department of Hospital Pharmacy, School of Pharmaceutical Sciences, The University of Osaka, Osaka 5650871, Japan.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
|October 6, 2025
PubMed
概括

埃索梅普拉通过抑制有机阴离子转运体2 (OCT2) 介导的氧化转运到背部根结质神经元中,有效地预防氧化诱导的外周神经病变 (OIPN). 这减少了药物积累和OIPN症状.

关键词:
埃索梅普拉 (esomeprazole) 是一种药物.有机离子载体 2 有机离子载体 2奥克沙利普拉丁诱导的外围神经病变质子抑制剂 质子抑制剂

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