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皮肤高级糖化终产品 (AGEs) 与骨矿物质密度在纵向上没有关联:鹿特丹研究

Mengyuan Cai¹, Jinluan Chen¹, Jiawei Li²

¹Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015GD, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

|October 6, 2025

概括

对于高级糖化终产品 (AGEs) 的皮肤自光 (SAF) 并没有预测随着时间的推移,骨矿物质密度 (BMD) 或骨骨分数 (TBS) 的变化. 这些发现表明,除了骨质疏松外,还有其他因素会影响AGE.

科学领域:

骨生物学和衰老研究.
代谢标志物和骨健康.
骨质疏松症和骨折风险评估.

背景情况:

先进的糖化终产物 (AGEs) 与骨折有关,但它们与骨密度的关联不清楚.
皮肤自发光 (SAF) 是累积AGE的非侵入性测量方法.
了解AGE在骨健康中的作用对于预测骨脆弱性至关重要.

研究的目的:

调查皮肤AGE (SAF) 与骨矿物质密度 (BMD) 和骨骨分数 (TBS) 的变化之间的纵向关联.

主要方法:

鹿特丹研究队列使用皮肤自光 (SAF) 和双能X射线吸收度 (DXA) 来测量BMD.
线性混合效应模型分析了SAF与纵向BMD和TBS的关联,并对混因素进行了调整.
相互作用分析探讨了因性别,糖尿病,脏疾病和双酸盐使用而改变效果.

主要成果:

在SAF和全身,腰椎或股骨部BMD变化之间没有发现显著的纵向关联.
随着时间的推移,SAF与椎骨分数 (TBS) 的变化无关.
虽然注意到与性别和糖尿病的相互作用,但分层分析显示没有显著的关联.

结论:

皮肤 AGEs (SAF) 不能预测 BMD 或 TBS 的纵向变化.
缺乏关联支持发现,AGE与骨折的联系是独立于BMD和TBS的.
骨质和肌肉特征可能会调解AGE和骨折风险之间的关系.

关键词:

高级糖化最终产品的高级糖化.骨矿物质密度骨矿物质密度皮肤自发光是一种自发光.脊椎骨的骨分数是什么

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