甲状腺眼病中的眼外肌肉扩大:系统性审查和元分析
Chris Zajner1, Angelica Hanna2, Michele Zaman3
1Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
概括
甲状腺眼病 (TED) 导致所有眼外肌肉 (EOMs) 显著扩大,特别是下直肠. 这一系统性审查量化了TED患者与对照人群之间的EOM大小差异.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
背景情况:
- 轨道结构的放射测量对于诊断甲状腺眼病 (TED) 和评估治疗疗效至关重要.
- 在TED患者的眼外肌肉 (EOM) 尺寸的具体变化仍然不完全理解.
- 了解EOM变化对于全面的TED评估至关重要.
研究的目的:
- 系统地审查和分析TED患者和对照组之间的EOM大小差异.
- 在TED中量化EOM直径,横截面积和体积变化.
- 为了更清楚地理解EOM参与TED的病理生理学.
主要方法:
- 进行了系统性审查和元分析,该协议在PROSPERO.上注册.
- 在EMBASE,Web of Science和OVID MEDLINE数据库中进行搜索,截至2024年6月5日.
- 包括比较TED患者与对照者的EOM测量的研究,并使用随机效应模型和子组分析分析数据.
主要成果:
- 分析了23项涉及2,708个TED轨道和1,221个控制轨道的研究.
- 分析显示,TED患者所有直肠肌肉的EOM直径显著增加 (下部:1.9毫米,中部:1.6毫米,上部:1.3毫米,横部:0.89毫米).
- 在TED患者中,所有直肠肌肉的EOM体积也显著增加 (下部:515毫米3,上部:609毫米3,中部:551毫米3,横部:288毫米3).
结论:
- 与对照人群相比,TED患者的下直肠肌肉显示出一致而明显的扩大.
- 在TED中,中间,上部和侧面直肠肌肉的扩大程度在研究中不太一致.
- 这些发现凸显了TED的显著EOM缩,不同肌肉之间的参与模式各不相同.
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