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纵向组织分析显示微环境变化与转移性乳腺癌中联合免疫疗法和向治疗反应相关

Jian-You Liao^1,2, Jien Wang¹, Hengyu Li³

¹Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Journal for immunotherapy of cancer

|October 6, 2025

概括

纵向瘤微环境 (TME) 多组体分析揭示了与转移性乳腺癌治疗反应相关的免疫细胞转移. 了解这些TME动态为评估治疗有效性提供了临床价值.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
基因组学就是基因组学.

背景情况:

询问瘤微环境 (TME) 对于了解治疗反应和疾病进展至关重要.
纵向组织分析和多omics集成存在挑战,但在临床环境中具有潜在价值.

研究的目的:

研究一种新型双特异抗体联合治疗对治疗耐药转移性乳腺癌中TME的影响.
为了定义与多omics分析集成的纵向活检的价值.

主要方法:

进行了转移性乳腺癌的多中心2期临床试验.
在治疗前和治疗后进行纵向瘤组织采样.
在334,183个细胞上利用单细胞RNA和T细胞受体测序.

主要成果:

在TME内观察到免疫细胞群和表型的显著时间转变,与治疗反应相关.
在没有反应的瘤中发现了调节性T细胞的激活和效应性T细胞,NK细胞和树突细胞的枯竭.
在TME中,免疫细胞群体和表型的时间转移得到证明.

结论:

纵向的TME多组分析为疾病过程提供了有价值的见解.
这种方法可以提高对转移性乳腺癌治疗反应的临床评估.

关键词:

乳腺癌乳腺癌乳腺癌组合疗法是一种联合疗法.免疫治疗是一种免疫疗法.瘤微环境 - - 瘤微环境

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相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...