乳腺癌下一代测序:当前的临床应用和未来的方向
Nur Fatihah Mohd Zuhdi1, Alaa Siddig1,2, Siti Norasikin Mohd Nafi1
1Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Annals of medicine
|October 6, 2025
概括
下一代测序 (NGS) 通过揭示基因组多样性和识别可操作的变化,促进了乳腺癌的精确医学. 像循环瘤DNA和单细胞测序等新兴技术为未来的诊断和治疗潜力提供了机会.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 生物技术是生物技术.
背景情况:
- 乳腺癌是一种异质性疾病,具有显著的死亡率.
- 欧米技术,特别是下一代测序 (NGS),对于推进瘤学的精准医学至关重要.
- 由美国临床瘤学会 (ASCO) 概述的基因组测试具有预后和诊断价值.
研究的目的:
- 审查NGS在乳腺癌中的演变和临床应用.
- 引导未来的研究,以改善乳腺癌治疗中的患者护理.
- 突出新兴技术在乳腺癌研究中的潜力.
主要方法:
- 在PubMed,谷歌学者和ResearchGate进行了全面的文献搜索.
- 专注于关键词:乳腺癌,HER-2低乳腺癌,循环瘤DNA,单细胞RNA测序和下一代测序.
- 精选的同行评审,高质量的英语文章供收录.
主要成果:
- NGS对乳腺癌的基因组和转录基因组特征进行了描述,确定了关键的变化.
- 像循环瘤DNA (ctDNA) 和单细胞测序等新兴技术显示出诊断,预后和监测的前景.
- 低HER2乳腺瘤存在持续的研究挑战,以及成本限制单细胞测序采用等障碍.
结论:
- NGS发现了乳腺癌的分子多样性,指导治疗和预测治疗反应/耐药性.
- 尽管瘤异质,ctDNA具有全面癌症管理的潜力.
- 单细胞分析提供了深入的见解,但需要进一步开发以广泛的临床使用.
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