在治疗耐药性抑郁症中,正面前带带皮质在情绪处理中的作用
Ana Rita Barreiros1,2,3,4, Isabella Breukelaar5, Prashanth Mayur6
1Brain Dynamics Centre, Westmead Institute for Medical Research, Sydney, NSW, Australia. ana.barreiros@sydney.edu.au.
Translational psychiatry
|October 6, 2025
概括
治疗耐药性抑郁症 (TRD) 在情绪处理过程中显示出转面前带带皮层 (rACC) 连接性的改变. 神经网络中的这些差异将TRD与健康对照和治疗敏感抑郁症区分开来.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 面前环状皮质 (rACC) 与治疗耐药性抑郁症 (TRD) 有关.
- 它在调节神经网络相互作用,特别是默认模式网络中的作用至关重要.
- 了解rACC连接差异可能会揭示TRD背后的机制.
研究的目的:
- 研究TRD患者的rACC的差异连接性.
- 在有意识 (超意识) 和无意识 (潜意识) 情绪处理期间检查rACC连接性.
- 将TRD患者与治疗敏感性抑郁症 (TSD) 患者和健康对照 (HC) 患者进行比较.
主要方法:
- 3T fMRI用于扫描31名TRD患者,35名TSD患者和37名HC患者.
- 参与者在超限和潜限条件下执行了引发面部表情情绪反应的任务.
- 基于种子和兴趣地区 (ROI) 的分析被用来评估rACC连接性.
主要成果:
- 与HC和TSD相比,TRD患者在潜意识的积极情绪处理过程中表现出与小脑和中圈的rACC连接性增加.
- 与TSD和HC相比,TRD患者在超额外的积极情绪处理过程中与海马体的rACC连接性降低.
- 在TRD中观察到改变的rACC连接模式,用于意识和非意识地处理积极的面部情绪.
结论:
- 涉及rACC的神经连接的改变将TRD与HC和TSD区分开来.
- 这些发现表明,rACC在TRD.中出现的持续性无花果中发挥了作用.
- 该研究强调了rACC连接在情绪调节和上下文化方面的重要性,特别是在非意识处理过程中.
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