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Updated: Jan 15, 2026

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由PTEN缺陷驱动的子宫内膜癌的进展需要miR-424

Maria Vidal-Sabanés1, Núria Bonifaci2,3, Raúl Navaridas4

  • 1Developmental and Oncogenic Signaling Group, Departament de Ciències Mèdiques Bàsqieus/Medicina Experimental, Universitat de Lleida. Institut de Recerca Biomèdica de Lleida, IRBLleida, Lleida, Spain.

Cell death & disease
|October 6, 2025
PubMed
概括

失去miR-424(322) ~503会损害子宫内膜癌细胞的增殖并恢复细胞灭绝,即使在PTEN缺乏的瘤中也是如此. 这种微RNA在子宫内膜癌的进展和TGFβ信号传递中发挥着关键作用.

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