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正常结肠和结肠癌中的肌体细胞:甲状腺激素信号传递的重要性
Mathieu Reslinger1, Michelina Plateroti2
1Institute of Genetics and Molecular and Cellular Biology, CNRS UMR7104-INSERM U1258-Université de Strasbourg, Illkirch, France.
Cell death & disease
|October 6, 2025
概括
甲状腺激素 (THs) 和TRα1受体对结肠健康和结肠直肠癌 (CRC) 至关重要,因为它们通过影响细胞信号传递. 它们在哺乳动物结肠生理学和CRC中的作用仍未得到充分研究.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 分子生物学分子生物学
背景情况:
- 甲状腺激素 (THs) 通过甲状腺激素核受体 (TRs) 调节肠道发育和平衡.
- TRα1信号通过WNT,NOTCH和BMP途径影响肠道干细胞,瘤形成和上皮-脑膜相互作用.
- 干细胞,包括癌症相关纤维细胞 (CAF),在结肠平衡和结肠直肠癌 (CRC) 中发挥着关键作用.
研究的目的:
- 审查T3和TRα1在结肠病理学中的作用,重点关注上皮层-流和瘤-流相互作用.
- 突出TH/TR信号传递在正常哺乳动物结肠和CRC中所了解的功能.
- 讨论TRα1突变和抗甲状腺激素-α (RTH-α) 综合征对肠道健康的影响.
主要方法:
- 关于TH/TR信号在结肠生理学和病理学方面的最新研究的文献综述.
- 分析涉及表皮层-脑膜相互作用的细胞-细胞信号通路.
- 检查与RTH-α综合征及其肠道表现相关的发现.
主要成果:
- THs和TRα1对于肠道干细胞生物学和瘤形成至关重要,通过调节信号通路.
- 流体细胞,特别是CAF,是结肠恒温和CRC发育的关键参与者.
- 哺乳动物结肠和CRC中TH/TR信号的功能尚未得到充分研究,尽管它在两变形中的作用已知.
结论:
- TH/TR信号传递,特别是TRα1,通过表皮层-层相互作用显著影响结肠病理学和CRC.
- 需要进一步的研究来阐明TH/TR信号在正常哺乳动物结肠中的精确机制及其在CRC中的作用.
- 了解TH/TR信号可能会为与RTH-α综合征相关的肠道并发症以及CRC的潜在治疗策略提供见解.
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