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参与5-HT是必要的EA介导改善中风后抑郁症

Bing Deng¹, Wenhui Di¹, Haoxi Long¹

¹South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.

Translational psychiatry

|October 6, 2025

概括

电 ?? 疗法通过调节5-西胺 (5-HT) 系统,有效地治疗中风后抑郁症. 这种传统治疗改善了抑郁行为和神经元活动,为中风后抑郁症 (PSD) 提供了一个有希望的替代方案.

科学领域:

神经科学是一个神经科学.
综合医学是一个整体的医学.
药理学药理学是指药理学的学科.

背景情况:

脑卒中后抑郁症 (PSD) 在五年内影响高达30%的中风幸存者.
目前西方医学对PSD的治疗方法缺乏重大突破.
传统针对PSD有希望,但其潜在机制需要阐明.

研究的目的:

研究电治疗中风后抑郁症 (PSD) 的生物机制.
探索5-基三胺 (5-HT) 系统在PSD病原和EA治疗中的作用.
在PSD的小鼠模型中比较EA与fluoxetine的疗效.

主要方法:

建立了一个PSD小鼠模型,使用双边原酶IV注射到中间前额叶皮层 (mPFC).
使用行为测试,免疫光,体内电生理学,mRNA测序和化学遗传学.
评估了在Baihui (GV20) 和Shenting (GV24) 针点的EA影响,包括向mPFC投射的背脊核 (DRN) 中的神经元活动.

主要成果:

电针 (EA) 在PSD小鼠中显著改善了类似抑郁的行为和神经元电生理活动.
EA的疗效与素类药物相当,而5-西胺 (5-HT) 系统与PSD有关.
EA治疗增加了DRN中的5-HT阳性神经元和mPFC中的5-HT水平;DRN神经元的切除阻止了EA的有效性.

结论:

这项研究阐明了针治疗PSD的生物机制,突出了通过DRN-mPFC通路对5-HT系统的调制.
电针 (EA) 通过影响神经元活动和神经递质系统,显示出对中风后抑郁症 (PSD) 的显著治疗潜力.
这些发现强调了针治疗PSD的临床和科学价值,为未来的治疗策略提供了洞察力.

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