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Updated: Jan 15, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
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通过局部祖先推断,改善了gnomAD中的等位基因频率

Pragati Kore1, Michael W Wilson2, Grace Tiao2

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

Nature communications
|October 6, 2025
PubMed
概括

局部祖先推断 (LAI) 揭示了混合种群中显著的等位基因频率差异,提高了基因组数据的准确性. 这种方法改进了变异解释,可能将一些变异从不确定的意义重新归类为良性.

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