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Updated: May 7, 2026

An In Vitro Organ Culture Model of the Murine Intervertebral Disc
08:03

An In Vitro Organ Culture Model of the Murine Intervertebral Disc

Published on: April 11, 2017

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在改变脊柱负荷的情况下,SDC4驱动椎间盘的纤维性重塑

Kimheak Sao1,2, Makarand V Risbud3,4

  • 1Graduate Program in Cell Biology and Regenerative Medicine, Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, USA.

Cell death & disease
|October 6, 2025
PubMed
概括

删除Syndecan 4 (SDC4) 保护了小鼠的椎间盘,避免因生理负荷变化而导致的退化. SDC4淘汰阻止了有害的矩阵变化,并保留了心弦细胞特征,突出显示了SDC4在磁盘平衡中的作用.

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