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Updated: Jan 15, 2026

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两个结构上不同的药物对LRRC8通道抑制的保存机制

Toshiki Yamada1, Paola Bisignano2, Erkan Karakas2

  • 1Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA.

Communications biology
|October 6, 2025
PubMed
概括

两个不同的LRRC8通道抑制剂,zafirlukast和pranlukast,共享一个共同的抑制机制. 这涉及破坏蛋白质-脂质相互作用,破坏毛孔的稳定性,提供新的治疗策略.

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