黑龙江省凯山病与蛋白P之间的地理空间关联:双变空间自相关性分析
Jiacheng Li1,2, Cheng Wang1,2, Guijin Li1,2
1Chinese Center for Endemic Disease Control, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.
Biological trace element research
|October 6, 2025
概括
与缺乏症相关的凯珊病没有显示与血清蛋白P水平的全球空间联系. 然而,当地分析确定了黑龙江省有针对性的预防和控制干预措施的关键地区.
科学领域:
- 流行病学 流行病学
- 营养科学 营养科学
- 空间分析 空间分析
背景情况:
- 凯珊病是中国的特有病,与缺乏有关.
- 有限的空间流行病学研究存在于凯珊病的流行率和营养.
- 了解空间关系对于有效的疾病控制至关重要.
研究的目的:
- 探索Keshan疾病患病率和血清蛋白P水平之间的双变空间自相关性.
- 确定黑龙江省凯山病的高风险地区.
- 为针对性疾病预防和控制策略提供证据.
主要方法:
- 对于流行数据的空间实证贝叶斯平滑.
- 与酶相关的免疫吸收试验 (ELISA) 检测血清蛋白P水平.
- 两变空间自相关分析 (全球和本地).
主要成果:
- 在蛋白P水平和Keshan疾病患病率之间没有发现全球空间自相关性.
- 当地空间分析显示了8个星团,包括3个高低和5个低高.
- 九个群体被确定为凯珊病的关键区域,其中三个群体在低群体中显示出集中风险.
结论:
- 虽然没有全球联系,但当地空间模式突出显示了具体的干预领域.
- 建议在已确定高风险,低区域开展有针对性的预防和控制工作.
- 优先考虑这些群体内或附近的居民可以减轻凯珊病的风险.
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