对神经母细胞瘤的F-AlF-NOTA-octreotide PET/CT进行病理验证
Yuxuan Liu1, Yuting Ma2, Han Wang1
1Department of Nuclear Medicine, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.
Scientific reports
|October 6, 2025
概括
这项研究表明,18F-AlF-NOTA-octreotide (18F-OC) PET/CT成像与神经母细胞瘤 (NB) 中的体静止素受体2 (SSTR2) 表达良好相关. 这种PET/CT方法可以帮助指导NB治疗和随访.
科学领域:
- 核医学就是核医学.
- 在瘤学瘤学.
- 放射化学 放射化学是指辐射化学.
背景情况:
- 索马托斯坦素受体2 (SSTR2) 定子发射断层扫描/计算机断层扫描 (PET/CT) 对于神经母细胞瘤 (NB) 管理至关重要,但可以显示非特异性吸收.
- 在神经内分泌瘤 (NETs) 中对SSTR PET/CT的现有研究可能由于生物学差异而不能完全转化为NB.
研究的目的:
- 评估18F-AlF-NOTA-octreotide (18F-OC) PET/CT成像参数与通过免疫组织化学 (IHC) 量化的SSTR2表达之间的关系.
- 评估18F-OC PET/CT对诊断和监测的有用性 NB.
主要方法:
- 追溯分析了71个病变,这些病变来自初始或经过治疗的NB患者,这些患者接受了18F-OC PET/CT.
- 对于SSTR2表达,PET/CT成像参数 (克伦宁分数,SUVmax,SUV平均) 与IHC分数 (HER2,IRS,H分数,Volante分数) 的相关性.
主要成果:
- 18F-OC的吸收和SSTR2的表达在NB瘤中明显高于瘤 (GNB) 和瘤 (GN).
- 77.9%的18F-OC PET/CT阳性病变被IHC.确认为SSTR2阳性.
- 图像参数与NB和总队列中的HER2,IRS和H分数有显著的正相关性,但在GNB/GN中没有.
结论:
- 18F-OC PET/CT成像和SSTR2 IHC分数在新诊断和残留NB之间存在很高的一致性.
- 18F-OC PET/CT提供了可以指导NB治疗和随访的分子证据.
- 这种相关性在GNB和GN中并不显著,这表明SSTR2表达模式差异.
关键词:
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