脊髓灰质炎病毒的重新激活和痴呆的风险
Vitaly Polisky1, Maria Littmann1, Aleksei Triastcyn2
1GSK, Heidelberg, Germany.
Nature medicine
|October 6, 2025
概括
包括带状疹在内的疹病毒 (VZV) 再激活与痴呆症风险增加有关. 带状疹疫苗可能会降低这种风险,这表明VZV的重新激活是可修改的痴呆症因素.
科学领域:
- 神经科学是一个神经科学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 脊髓灰质炎病毒 (VZV) 建立了终身潜伏状态,其重新激活可以导致疹 (shingles).
- 建议VZV的重新激活是痴呆症发展的潜在因素,但这种关联的程度需要进一步调查.
研究的目的:
- 调查VZV重新激活和痴呆风险之间的关系.
- 评估疹疫苗对痴呆症风险的影响.
主要方法:
- 一个大规模的纵向分析超过1亿美国人的健康记录.
- 统计模型对近400个人口,临床和行为因素进行了控制.
主要成果:
- 与单次发作相比,反复出现的HZ发作与痴呆症的风险更高有关.
- 与肺炎球菌疫苗接种相比,HZ疫苗接种与痴呆症风险降低有关.
- 黄斑疫苗的保护作用随着时间的推移而减弱,与对黄斑疫苗的保护相关;多剂量和高风险个体显示出更大的痴呆风险降低.
结论:
- VZV的重新激活被强烈认为是痴呆症的可修改风险因素.
- 热带疫苗接种可以提供对痴呆症的保护性益处,特别是在及时并重复使用时.
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