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第一个三个月子宫长度查和早产风险:系统性审查和元分析

Sedigheh Hantoushzadeh^1,2, Nafiseh Saedi³, Kyana Jafarabady⁴

¹Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

BMC pregnancy and childbirth

|October 6, 2025

概括

第一个三个月的宫长度 (CL) 测量与早产 (PTB) 风险有关. 在早期分娩中观察到较短的CL,但其用于预测PTB的临床用途仍然不确定.

科学领域:

产科和妇科产科和妇科
围产儿医学围产儿医学
生殖健康生殖健康

背景情况:

在预测早产 (PTB) 时测量宫长度 (CL) 在头三个月的临床意义尚未得到充分确立.
现有证据需要综合来澄清早期CL和PTB风险之间的关联.

研究的目的:

系统地审查并对第一季度宫长度 (CL) 测量与早产风险 (PTB) 之间的关联进行元分析.

主要方法:

遵守PRISMA指南和进行PROSPERO注册 (CRD42023462610).
在2024年1月29日之前进行全面的数据库搜索 (PubMed,Scopus,科学网,Cochrane图书馆).
包括RCT,观察性和回顾性研究;数据提取和两位独立审稿人的偏差风险评估;随机效应模型元分析.

主要成果:

分析了五项涉及16053例怀孕的研究.
在34周 (平均差异-0.59毫米) 和37周 (平均差异-0.23毫米) 之前分娩的个体中发现了明显较短的CL.
观察到异质性 (I2=72.56%和I2=76.26%分别).

结论:

第一个三个月的CL测量显示了与早产 (PTB) 风险的显著关联.
尽管存在这种关联,但研究异质性和生理变异限制了其作为预测工具的当前临床实用性.
建议使用标准化方案和更大的队列进行进一步的研究,以确定其在PTB查和早期干预中的作用.

关键词:

宫的长度宫的长度第一个三个月的孕期.进行元分析分析.过早出生过早的出生系统性审查系统性审查

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