评价微生物调节作为辐射相关的预防策略:一篇综述
Hong-Xiang Ou1,2, Yu Chen1,2, Da-Li Zheng1
1Fujian Key Laboratory of Oral Diseases &Fujian Provincial Engineering Research Center of Oral Biomaterial &School and Hospital of Stomatology, Stomatological Key Lab of Fujian College and University, Fujian Medical University, 246 Yang Qiao Middle Road, Fuzhou, China.
Head & face medicine
|October 7, 2025
概括
头癌的放射治疗通过改变口腔微生物导致与辐射相关的 (RRC). 使用益生菌和改善口腔护理的双重干预可以防止RRC.
科学领域:
- 口腔瘤学 在口腔瘤学
- 微生物生态学 微生物生态学
- 辐射瘤学 辐射瘤学
背景情况:
- 头角状细胞癌 (HNSCC) 的放射治疗导致与辐射相关的 (RRC),影响患者的生活质量.
- 目前对RRC的理解主要集中在直接辐射的影响上,如唾液功能下降,忽视了微生物的转变.
- 新出现的证据表明,饮食变化和口腔微生物失生症通过促进 cariogenic 细菌和真菌加剧RRC.
研究的目的:
- 在HNSCC患者中审查辐射诱导的口腔微生物群变化.
- 为了分析放射治疗后的特定空性种群的扩散.
- 探索基于微生物生态学的新型RRC预防策略.
主要方法:
- 文献综述侧重于放射治疗后口腔微生物群的变化.
- 对细菌和真菌种群的记录转移进行分析,包括特定的菌性物种.
- 关于预防RRC的双重干预协议的建议.
主要成果:
- 放射治疗与明显的口腔微生物群失生症有关.
- 观察到 cariogenic 细菌 (如 Streptococcus mutans, Lactobacillus) 和真菌 (如 Candida albicans) 的明显增殖.
- 像Prevotella melaninogenica,Veillonella和Actinomyces这样的特定种类也在增加.
结论:
- 口腔微生物转移是RRC发展中的一个关键,但尚未被充分探索的机制.
- 拟议的双重干预包括益生菌补充剂和增强的口腔护理.
- 需要严格的临床试验来验证这种预防策略的有效性.
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