谨慎选择甜味剂 - - 儿童肥胖的营养学研究
Daniel Wang Qiu1, Chia-Min Kuo2, Shih-Yuan Hsu2
1College of Medicine, Taipei Medical University, Taipei, Taiwan.
Nutrition & metabolism
|October 7, 2025
概括
儿童肥胖风险与甜味基因和人工甜味剂摄入有关. 诸如糖之类的特定甜味剂与基因相互作用,影响儿童的肥胖风险和身体组成.
科学领域:
- 儿童营养学 儿童营养学
- 肥胖的遗传学 肥胖的遗传学
- 消费的甜味剂消费的甜味剂.
背景情况:
- 调查了甜味和肥胖基因与儿童甜味剂摄入之间的联系.
- 检查与儿童肥胖风险相关的基因甜味剂相互作用.
- 使用台湾青春期纵向研究 (TPLS) 的数据来最大限度地减少环境混因素.
研究的目的:
- 探索特定的甜味和肥胖相关基因与儿童甜味剂消费模式的关联.
- 了解遗传因素和甜味剂摄入量与儿童肥胖风险之间的相互作用.
主要方法:
- 从TPLS参与者的遗传采样,人体测量和饮食回忆.
- 使用NNS-FFQ.评估非营养甜味剂 (NNS) 摄入量.
- 后勤回归分析基因型-甜味剂相关性和基因-甜味剂相互作用,控制混因素.
主要成果:
- 摄入更多的阿塞苏尔法,苏克拉和醇与较低的BMI Z-分数和体脂有关.
- 糖摄入量和甜味基因之间显著的相互作用影响腰部和部的比例.
- 肥胖和甜味受体基因 (ADCY9,TFAP2B,TAS1R2,TAS1R3) 与甜味剂消费相关;rs7498665与BMI Z-score相关.
结论:
- 遗传因素是甜味剂消费的基础,并与变体相互作用,影响儿童肥胖风险.
- 研究结果为公共卫生和个性化营养策略提供了洞察力,以打击儿童肥胖.
- 为了有效的个性化策略,需要对更大样本和综合遗传/环境因素进行进一步的研究.
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