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克洛扎相关的肺栓塞:呈现特征和结果,英国药监数据,1990-2022年
Susanna Every-Palmer1,2, Rupert Nelson2, Alice Hyun Min Kim3
1Department of Psychological Medicine, University of Otago, Wellington, New Zealand.
概括
与克洛扎相关的肺栓塞对患者来说是一个严重的风险,近一半报告的病例导致死亡. 肥胖和久坐不动行为与致命的结果有关,强调需要主动管理.
科学领域:
- 药物监督 药物监督 药物监督
- 心血管安全心血管安全
- 精神病药物监测 精神病药物监测
背景情况:
- 肺栓塞 (PE) 在与其他抗精神病药物或一般人群相比,在用克洛扎宾治疗的患者中更为普遍.
- 克洛扎是一种非典型的抗精神病药物,用于治疗耐药精神分裂症.
研究的目的:
- 调查英国与克洛扎使用相关的肺栓塞的临床特征和结果.
- 为了确定与克洛扎相关的肺栓塞的风险因素和趋势.
主要方法:
- 从1990年到2022年,英国黄卡报告了与克洛扎相关的呼吸道,胸部和中关节疾病的分析.
- 在对474份独一无二的报告应用严格排除标准后,包括了339起案件.
- 统计分析以确定与致命结果相关的因素.
主要成果:
- 在339名与克洛扎相关的PE患者中,有164人 (48%) 死亡. 克洛沙平的平均剂量为336.7毫克/天.
- 勃起前列腺发作的平均年龄为45岁,平均治疗持续时间为2.9年.
- 肥胖 (aOR 2.61) 和久坐 (aOR 6.07) 与致命结局有显著的相关性. 39%的非致命血栓和22%的致命血栓发生在治疗的第一年.
结论:
- 与克洛扎相关的肺栓塞是一种严重的临床问题,死亡率高.
- 预防,早期识别和及时管理的积极策略对于克洛扎宾患者至关重要.
- 肥胖和久坐不动的生活方式等风险因素在治疗克洛扎宾患者时需要注意,以减轻PE风险.
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