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Updated: Jan 15, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

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在多发性硬化症中对ocrelizumab进行回顾性药监测研究:对FDA不良事件报告系统 (FAERS) 数据库的分析

Hong-Yan Ma1, Ya-Bin Ma2, Pei-Jie Ye3

  • 1Department of Pharmacy, Shenzhen Longhua District Central Hospital, Shenzhen, China.

Medicine
|October 7, 2025
PubMed
概括

这项研究分析了真实世界的ocrelizumab安全数据,证实了已知的不良事件 (AE),如感染,并确定了多发性硬化症患者的新潜在信号,如脱发和败血症.

关键词:
公平的人是公平的.药物不良反应 药物不良反应多发性硬化症 多发性硬化症这就是Ocrelizumab.药物监督和药物监督

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Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

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Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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