年龄不会影响老年成人创伤患者的术后乳酸盐值
Kristin Salottolo1, Alexander Knippenberg2, Michael Fisher2
1Trauma Research Department, Swedish Medical Center, Englewood, Colorado, USA.
Journal of the American Geriatrics Society
|October 7, 2025
概括
年龄不会显著影响老年成人创伤患者的术后乳酸水平. 这项研究没有发现患者年龄和乳酸值之间的关联,这表明目前的解释准则适合这个人口群体.
科学领域:
- 老年医学 老年医学
- 创伤外科 手术 创伤外科
- 关键护理医学 关键护理医学
背景情况:
- 乳酸监测对于识别高风险患者至关重要,但目前的解释不考虑年龄.
- 年龄对老年人术后乳酸水平的影响仍未得到充分研究.
- 这项研究研究了年龄作为老年创伤患者乳酸值的潜在改变因素.
研究的目的:
- 确定65岁及以上患者的年龄和术后静脉乳酸盐 (pVL) 水平之间的关联.
- 为了检查年龄是否改变了接受手术的老年成人创伤患者的pVL的解释.
主要方法:
- 对284名年龄≥65岁的患者进行了回顾性观察性研究,这些患者接受了手术干预.
- 术后静脉乳酸 (pVL) 和患者年龄的分析,连续和分类.
- 按混因素进行分层分析,包括生存率,ICU入院,受伤严重程度和脆弱性.
主要成果:
- 在连续或分类检查时,没有发现年龄和pVL之间的显著关联 (p > 0.05).
- 按ICU入院,受伤严重程度,生存率和脆弱性的分层分析也显示没有显著的pVL年龄关联.
- 平均年龄为80岁,其中37%的患者≥85岁;13%的pVL≥3 mmol/L.
结论:
- 年龄不是解释老年成人创伤患者术后乳酸值的一个重要因素.
- 目前的乳酸解释值似乎适用于老年创伤人口.
- 可能不需要进一步的研究来调整基于这个群体年龄的乳酸解释.
相关概念视频
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
232
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
232
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
234
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
234
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
227
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
227
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
196
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
196
Pharmacodynamics in Geriatric Patients: Effects of Age
187
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
187
Drug Dosing: Geriatric Patients
225
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
225


