调查卵巢衰老标志物和荷尔蒙调节在更年期过渡的调节
Samah Amer Hammood1, Noor Alamer2, Mohammed Kareem S ALquraish3
1Department of Laboratory Investigation, Science Faculty, University of Kufa, Najaf, Iraq. samahalobaid@uokufa.edu.iq.
Cellular and molecular biology (Noisy-le-Grand, France)
|October 7, 2025
概括
低维生素D和抗穆勒尔激素 (AMH) 水平与更严重的绝经症状和衰老有关. 补充可能有助于减少症状,并改善更年期妇女的生育能力.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 老年学是指老年学的学科.
- 营养科学 营养科学
背景情况:
- 卵巢衰老是一种自然过程,导致更年期和降低生育能力.
- 卵巢功能下降受到内分泌,遗传和代谢因素的影响.
- 更年期症状可以显著影响生活质量.
研究的目的:
- 研究更年期症状与维生素D,抗米勒尔激素 (AMH) 和其他关键生殖激素的血清水平之间的关系.
- 探索这些因素对更年期的时间的影响.
- 为了确定预测更年期症状严重程度的潜在生物标志物.
主要方法:
- 这项研究涉及92名来自伊拉克纳贾夫省的妇女.
- 数据收集包括关于更年期症状和人类学 (年龄,体重,身高) 的问卷.
- 使用ELISA测量了FSH,25-基维生素D,AMH和LH的血清水平.
主要成果:
- 血清AMH和维生素D水平与绝经后妇女的更年期症状和年龄之间发现了显著的负相关性.
- 维生素D水平也显示了与年龄,抑郁症得分和BMI的负相关性.
- 较低的AMH和维生素D与更严重的发热,心脏不适,抑郁,易怒,膀问题和肌肉骨疼痛有关.
结论:
- 低血清AMH和维生素D水平可能会加剧更年期症状.
- 这些发现表明了管理更年期的潜在治疗点.
- 补充维生素D,AMH和生殖激素调节剂,以及改变生活方式,可能有利于经历生育能力下降和严重症状的更年期妇女.
相关概念视频
Menopause
3.5K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
3.5K
Hormonal Regulation of the Menstrual Cycle
1.5K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
1.5K
Hormonal Control of the Ovarian Cycle
6.4K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
6.4K
Oogenesis
69.0K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
69.0K
Hormonal Regulation
35.7K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
35.7K
Hormonal Regulation
47.7K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
47.7K


