在患有糖尿病黄斑的患者中,阿弗利塞普特8.0毫克的真实世界功能和解剖结果
Gabriel Castilho S Barbosa1,2, Suraj Bala1,3, Nitesh Mohan1
1Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Journal of vitreoretinal diseases
|October 7, 2025
概括
高剂量aflibercept (HDA) 降低了视网膜胀,并维持了糖尿病黄斑患者的视力. 然而,许多患者需要经常注射,并且仍然有持续的黄斑液,这表明正在进行的治疗挑战.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理疗法 药理疗法 药理疗法
背景情况:
- 糖尿病黄斑 (DME) 是糖尿病患者视力丧失的主要原因.
- 目前的治疗方法旨在减少黄斑胀并保持视力敏.
- 高剂量aflibercept (HDA) 是一种新兴的DME治疗选择.
研究的目的:
- 评估使用HDA治疗的DME患者的临床结果.
- 评估治疗间隔,解剖学变化和视力敏度.
- 确定与DME的HDA治疗相关的挑战.
主要方法:
- 67名DME患者 (100只眼睛) 的回顾性,单中心研究.
- 患者至少接受了3次HDA注射,其负载剂量定义.
- 结果包括治疗间隔维持 (≥7周),最佳校正视敏度 (BCVA) 和中央子场厚度 (CST).
主要成果:
- 平均CST从基线到最后一次访问显著下降 (P = .025).
- 在整个研究期间,BCVA保持稳定 (P = .676).
- 32%的眼睛无法保持≥7周的间隔;这些眼睛的基线CST (P = .045) 较高,90%的眼睛有持续的黄斑液.
结论:
- 在DME患者中,HDA有效降低了CST并稳定了BCVA.
- 频繁的注射和持续的黄斑液仍然是一个重大挑战.
- 对于慢性,耐治疗的DME,需要优化治疗策略.
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