奥西默提尼布加上强化放射治疗治疗晚期EGFR突变非小细胞肺癌:一个多中心,单臂,第二阶段试验
Sagus Sampath1, Sawsan Rashdan2,3, Puneeth Iyengar3,4
1Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA, USA.
EClinicalMedicine
|October 7, 2025
概括
将放射治疗添加到奥西默蒂尼布治疗中,显著改善了晚期EGFR突变非小细胞肺癌患者的无进展生存率. 这种组合疗法显示出有前途的疗效,并且耐受性良好,提供了潜在的少毒性选择.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学瘤学 医学瘤学
背景情况:
- 患有晚期EGFR突变非小细胞肺癌 (NSCLC) 的患者通常在两年内经历疾病进展,尽管EGFR抑制剂的反应率很高.
- 巩固性辐射疗法 (RT) 正在研究延长这些患者的疾病控制.
研究的目的:
- 评估巩固性辐射疗法 (RT) 在长期控制EGFR突变非小细胞肺癌 (NSCLC) 患者的疾病控制中的疗效.
- 评估这种联合治疗方法的安全性和耐受性.
主要方法:
- 一个多中心,单臂的第二阶段试验招募了患有晚期EGFR突变NSCLC的患者,这些患者接受了osimertinib.
- 经过8周的奥西默蒂尼布治疗后,病情稳定或反应良好的患者接受了对残留病变的巩固性RT,随后继续服用奥西默蒂尼布.
- 评估了无进展生存 (PFS),总生存 (OS) 和毒性.
主要成果:
- 在42名注册患者中,32人接受了整合性RT. 中位数PFS为32.3个月,中位数OS为45个月.
- 奥西默蒂尼布治疗的中位持续时间为32.4个月.
- 与奥西默提尼布相关的毒性通常为1-2级,其中两名患者患有肺炎.
结论:
- 奥西默提尼布加整合性RT耐受性良好,在晚期EGFR突变NSCLC中显示出有前途的疗效.
- 这种策略可能比多种药物疗法更少复杂和有毒,因此在正在进行的随机试验中需要进一步调查.
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