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火星尘埃模拟剂对肺部的潜在毒性影响

Jie Ji¹, Jasmine R Petriglieri², Francesco Turci³

¹Unit of Integrative Toxicology, Karolinska Institutet, Stockholm, Sweden.

|October 7, 2025

概括

暴露于火星尘埃模拟剂 (JSC Mars-1) 可能会损害肺部. 研究表明,它增加了肺细胞中的氧化应激和免疫反应,这表明宇航员的潜在肺毒性.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
航空航天医学航空航天医学

背景情况:

太空探索需要了解外星尘埃对健康的风险.
火星尘埃模拟剂 (JSC Mars-1) 用于建模潜在的暴露.
肺部毒性是宇航员的一个关键问题.

研究的目的:

为了调查JSC Mars-1的潜在肺毒性.
分析暴露于火星尘埃模拟剂的人类支气管上皮细胞中的分子和细胞反应.
为了确定尘埃引起的肺损伤的生物标志物.

主要方法:

利用一个先进的多细胞肺粘膜模型与人类支气管上皮细胞在空气液体接口.
应用了JSC Mars-1模拟剂在不同的剂量 (55,222,890μg/cm2) 和一个PBS假控制.
测量了基因表达 (HMGB1,HMOX-1,SOD3,IL-6,TNF-α,CXCL8,TLR4),反应性氧物种 (ROS) 和细胞毒性.

主要成果:

JSC Mars-1暴露增加了与死相关的HMGB1基因表达,以剂量依赖的方式.
细胞活性氧物种 (ROS) 水平和抗氧化基因表达 (HMOX-1,SOD3) 增加.
免疫反应标志物 (IL-6,TNF-α,CXCL8) 升高,而TLR4表达减少.

结论:

JSC Mars-1模拟剂在肺上皮细胞中诱导细胞毒性,氧化应激和炎症性免疫反应.
这些发现表明,火星尘埃暴露可能会对肺部产生毒性影响.
该研究提供了对太空探索不利呼吸系统影响的分子机制的见解.

关键词:

呼吸系统药物呼吸系统药物太空医学太空医学太空科学空间科学

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