血清金属体特征及其对慢性病的影响:一项比较研究
Jiuyi Jiang1,2, Lingxiao Hu1,3, Chunmei Dai1,2
1Department of Medical Laboratory, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.
International journal of general medicine
|October 7, 2025
概括
慢性病 (CKD) 患者表现出金属水平的变化,其中 (Al), (V) 和 (Pb) 等特定金属预测了CKD发病的发生. 监测这些金属可能有助于早期检测和评估疾病进展.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 毒理学 毒理学 毒理学
背景情况:
- 流行病学研究表明,金属暴露与功能障碍之间存在联系.
- 慢性病 (CKD) 是一个日益严重的公共卫生问题,病因复杂.
- 了解金属在CKD病原体中的作用对于预防和治疗至关重要.
研究的目的:
- 为了研究CKD患者的金属形状.
- 为了确定金属度和功能标志物之间的关系.
- 为了识别与CKD发病和进展相关的金属.
主要方法:
- 一项队列研究涉及341名CKD患者和60名健康对照.
- 对26种金属元素的血清水平的评估.
- 分析功能标志物,包括尿素,肌素,尿酸,囊素C和C1q.
- 后勤回归模型用于识别CKD发病和进展的预测因素.
主要成果:
- 与健康对照组相比,CKD患者对18种金属的血清度显著不同.
- (Al), (V), (Co), (Ga), (Cs) 和 (Pb) 的血清水平被确定为CKD发病的独立预测因素.
- (Li),V, (Mo) 和Cs等金属与CKD进展有关.
- 在几个金属对之间发现了显著的相关性,包括Al和V,Al和Ga,V和Ga之间的正相关性.
结论:
- 患有CKD的患者表现出明显的血清金属形状.
- 特定的金属 (Al,V,Co,Ga,Cs,Pb) 与CKD发病有关,而其他金属 (Li,V,Mo,Cs) 与其进展有关.
- 监测V,Pb和Mo等金属的血清水平可能有助于早期发现CKD和评估进展.
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