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血液转化生长因子-β1 (TGF-β1) 水平和多克索鲁比化疗后的心脏功能参数之间的相关性

Mukhlis Yazid¹, Muhadi Lnu¹, Sukamtoe Koesnoe²

¹Cardiology, Cipto Mangunkusumo National General Hospital, Jakarta, IDN.

|October 7, 2025

概括

转化生长因子-β1 (TGF-β1) 与大多数癌症患者的心脏功能没有相关性. 然而,较高的TGF-β1水平与接受较高累积多克索鲁比辛剂量的患者的腹痛功能障碍有关.

科学领域:

心脏病学心脏病学
在瘤学瘤学.
生物化学生物化学

背景情况:

doxorubicin 化疗可以引起显著的心脏毒性,影响心脏功能.
转化生长因子β1 (TGF-β1) 与心脏纤维化和多克索鲁比诱导的心脏毒性有关.
有限的人类研究探讨了TGF-β1与多克索鲁比心脏毒性的联系.

研究的目的:

评估血清TGF-β1水平与心脏功能参数之间的相关性.
评估喷射分数 (EF),E/A,E/E,TAPSE和GLS在多克索鲁比化疗后的情况.
调查TGF-β1作为多克索鲁比心脏毒性的潜在生物标志物.

主要方法:

在56名癌症患者的横截面研究,在doxorubicin. 3-12个月后进行.
通过心声学测量血清TGF-β1水平和心脏功能.
使用相关性分析 (皮尔森/斯皮尔曼) 在p < 0.05.05时设置显著性.

主要成果:

在总体队列中,TGF-β1与EF,E/A,E/E,TAPSE或GLS之间没有显著的相关性.
在累计多克索鲁比辛剂量≥600 mg/m2 (n=30) 的患者中,TGF-β1和E/E'之间发现了显著的相关性.

结论:

在一般队列中,TGF-β1与大多数心脏功能指数没有相关性.
在接受更高剂量多克索鲁比的患者中,TGF-β1与E/E' (透缩功能障碍) 有显著的相关性.
TGF-β1可能是抗环素诱导心脏纤维化的一个生物标志物,特别是在较高的累积剂量时.

关键词:

心脏有毒性心脏有毒性化疗化疗是一种化学疗法.德克索鲁比辛 (doxorubicin) 是一种药物.射出分数的射出分数转变的增长因子-β1

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