可比的临床和胚胎结局在流体和卵泡阶段控制的卵巢过度刺激:一个回顾性队列研究
Feng Gao1, Nicolás Garrido2, Juan Manuel Mascarós Martínez2
1Kindbody - San Francisco, San Francisco, California.
F&S reports
|October 7, 2025
概括
在体外受精 (IVF) 中的质阶段刺激显示了与卵泡阶段刺激相似的结果. 这种灵活的方法可能会改善年轻患者的囊胞活检率.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精过程中受精.
- 卵巢刺激 卵巢刺激
背景情况:
- 控制性卵巢过度刺激 (COH) 是体外受精 (IVF) 的一个关键组成部分.
- 刺激方案可以在月经周期的卵泡或质阶段启动.
- 对比这两个刺激阶段的疗效对于优化试管婴儿结果至关重要.
研究的目的:
- 为了比较COH周期中黄质阶段和卵泡阶段刺激之间的临床和胚胎学结果.
- 评估刺激阶段对怀孕率和其他关键IVF指标的影响.
主要方法:
- 对12442名患者进行了18062次试管婴儿周期的回顾性队列研究.
- 患者接受的COH始于毛囊或质阶段.
- 排除标准包括新鲜转移,第三天转移和子宫内膜接受度差.
主要成果:
- 临床怀孕率相似:68.44% (卵泡) 和67.67% (乳房).
- 质阶段刺激需要更高的FSH剂量,但产生了可比的刺激持续时间.
- 虽然毛囊阶段刺激总体上获得了更多的卵细胞,但在配对分析中,质阶段刺激的比率更高.
- 35岁以下的患者在质阶段刺激后的囊胞活检率较高 (61.01%对比55.37%).
- 卵细胞成熟,受精和euploid胚胎的速度没有显著差异.
结论:
- 状相刺激提供了与IVF中的卵泡相刺激相似的临床和胚胎学结果.
- 它代表了一种灵活而有效的替代性刺激策略.
- 在35岁以下的患者中,状体阶段刺激可能会提高囊胞活检率.
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