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对于结核病诊断的异热放大技术的进展

Nuttapon Jirakittiwut¹, Panan Ratthawongjirakul¹

¹Center of Excellence for Innovative Diagnosis of Antimicrobial Resistance, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.

Journal of clinical laboratory analysis

|October 7, 2025

概括

同热放大技术在资源有限的环境中提供快速和可访问的结核病 (TB) 检测. 这些方法,包括循环介导同热放大 (LAMP),对于推进终结结核病战略至关重要.

科学领域:

分子诊断学分子诊断
传染病检测发现传染病检测
生物技术是生物技术.

背景情况:

结核病 (TB) 诊断在资源较少的环境中很困难,因为对先进工具的访问有限.
异热放大技术,如循环介导异热放大 (LAMP),为可访问的结核病检测提供了有前途的解决方案.
其他技术,如链位移放大 (SDA),螺旋酶依赖放大 (HDA),重组酶聚合酶放大 (RPA) 和滚动周期放大 (RCA) 正在开发用于临床检测 (POCT).

研究的目的:

审查用于结核病检测的常见同热放大技术.
突出结核病诊断这些技术的优点和局限性.
讨论它们在各种样本类型中的适用性以及日常使用的潜力.

主要方法:

从2000年到2024年9月,在PubMed和Scopus上进行了系统的文献搜索.
关键词包括各种异热放大方法与"结核病"相结合.
审查的重点是这些技术的方法,性能和应用.

主要成果:

同热放大技术的特点是它们在结核病诊断中的方法,优势和局限性.
这些方法很容易执行,在几个小时内提供快速结果,以便及时治疗.
一些技术正在常规使用,而另一些技术正在评估中,显示出对结核病控制的巨大潜力.

结论:

同热放大技术是对抗结核病的重要分子工具.
它们的快速和可访问性支持了终结结核病战略的目标.
这些方法对于改善资源有限的环境中的结核病诊断至关重要.

关键词:

在IS6110中使用.结核菌菌菌菌复合体结核菌菌结核菌复合体异热放大放大异热放大放大结核病IS108181 这种疾病

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