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专家共识定义了慢性骨髓性白血病慢性阶段治疗不耐受性的定义
Ehab Atallah1, Michael S Broder2, Onyee Chan3
1Medical College of Wisconsin, Milwaukee, WI, United States.
专家在慢性髓性白血病 (CML) 患者中定义了治疗不耐受性,这些患者接受了氨酸激酶抑制剂 (TKI) 治疗. 这种以患者为中心的定义旨在规范护理并改善CML-CP患者经历不良事件的生命质量.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 氨酸激酶抑制剂 (TKIs) 在慢性阶段 (CML-CP) 治疗中彻底改变了慢性髓性白血病,显著提高了生存率.
- 与TKIs相关的不良事件 (AEs) 可能会对患者的生活质量,治疗坚持和治疗疗效产生负面影响.
- 目前,由于缺乏对TKI治疗不耐受性的标准化定义,导致临床管理实践变化.
研究的目的:
- 建立基于共识的,以患者为中心的TKI治疗不耐受性在CML-CP的定义.
- 开发一种用于评估TKI治疗不耐受性的工具.
- 在不耐受症的背景下,为管理TKI治疗提供建议.
主要方法:
- 采用了经过修改的Delphi小组方法,涉及13名专家.
- 专家小组成员根据TKI特征,AE干扰和管理策略评估了96个独特的患者场景.
- 通过文献审查和小组讨论达成共识.
主要成果:
- 建立了TKI治疗不耐受性的共识定义,重点是经常干扰日常活动并需要修改治疗的副作用.
- 专家小组成员在患者情景方面达成了近乎普遍的共识 (99%).
- 开发了一个评估患者不耐受性和管理建议的工具.
结论:
- 新定义的以患者为中心的TKI治疗不耐受性治疗方法在CML-CP中代表了标准化护理的重大进展.
- 该框架促进了管理TKI治疗的平衡方法,支持临床医生和患者之间的共享决策.
- 标准化TKI不耐受性的定义和管理对于优化CML-CP患者的长期结果和生活质量至关重要.
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