来自癌症相关纤维细胞的血栓素-4降低了胃癌细胞中ERBB2的表达

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Updated: Jan 15, 2026

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Gen Tsujio1,2,3, Masakazu Yashiro1,2,3, Takashi Sakuma1,2,3

  • 1Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.

Carcinogenesis
|October 7, 2025
PubMed
概括

与癌症相关的纤维细胞 (CAF) 和血栓松丁-4 (THBS4) 降低了胃癌 (GC) 中的HER2表达,导致抗HER2治疗耐药性. 像 gabapentin 这样的 THBS4 抑制剂可以克服这种抵抗.

关键词:
有HER2阳性的胃癌.与癌症相关的纤维细胞.gabapentin gabapentin 是一个药物.瘤内部的异质性血栓松丁-4的使用情况

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